GeneTex
United States (US)

Bestrophin antibody [E6-6]

GTX30219_1367_WB_18121410_304.jpg

Cat No. GTX30219

Host Mouse
Clonality Monoclonal
Clone Name E6-6
Isotype IgG1
Application WB, ICC/IF, IHC-P, IHC-Fr, IP
Reactivity Human, Dog, Pig, Primate
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1000
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

68 kDa. ( Note )

Specificity/Sensitivity

This product does not react with Rat.
PROPERTIES

Form

Liquid

Buffer

Ascites, 0.1% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide conjugated to KLH corresponding to the C-terminus of human Bestrophin 1 (KDHMDPYWALENRDEAHS) [UniProt# O76090]

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Bestrophin 1,Arb,Best,Bmd,Best1V1Delta2,Rp50,Tu15B,Vmd2,Best1

Background

Best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). It is inherited and has an early onset. Bestrophin is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.
DATA IMAGES
GTX30219_1367_WB_18121410_304.jpg

GTX30219 WB Image

WB analysis of human RPE cell lysate using GTX30219 Bestrophin antibody[E6-6].

Package List Price ($)
$ 339