GeneTex
  • Country / Location Selection

United States (US)

Bestrophin antibody

Anti-Bestrophin antibody used in IHC (Paraffin sections) (IHC-P). GTX14928

Cat No. GTX14928

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P, IP, ELISA

Reactivity

Human, Mouse, Rat, Monkey
Package
100 μg ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500
ICC/IF 1:100
IHC-P Assay dependent
IP 1:200
ELISA 1:10000
Not tested in other applications.

Calculated MW

68 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine pH7.4-7.9, 30% Glycerol, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.65 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Mid-Region Synthetic peptide corresponding to unique amino acid sequences on human Bestrophin 1 protein.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

bestrophin 1 , ARB , BEST , BMD , Best1V1Delta2 , RP50 , TU15B , VMD2

Cellular Localization

Cell membrane

Background

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]

Database

DATA IMAGES

Anti-Bestrophin antibody used in IHC (Paraffin sections) (IHC-P). GTX14928

GTX14928 IHC-P Image

IHC-P analysis of mouse eye tissue using GTX14928 Bestrophin antibody.
Dilution : 1:50

REFERENCE

There are currently no references for Bestrophin antibody (GTX14928). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for Bestrophin antibody (GTX14928). Be the first to share your experience with this product.
Package List Price ($)
$ 379