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Bim antibody

Anti-Bim antibody used in Immunohistochemistry (IHC). GTX27888
Anti-Bim antibody used in Western Blot (WB). GTX27888
Anti-Bim antibody used in Western Blot (WB). GTX27888

Cat. No. GTX27888

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA, IHC

Reactivity

 Human, Mouse, Rat
Package
100 μg ($479)
See all Bim products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1μg/ml
IHC-P Assay dependent
ELISA Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

22 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide corresponding to aa 22-40 of human Bim. The sequence is identical to that of mouse and is different by one amino acid from that of rat.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BAM , BCL2 like 11 , BCL2L11 , BIM , BOD , Bim

Cellular Localization

Endomembrane system,Mitochondrion

Background

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

Database

Research Area

DATA IMAGES

Anti-Bim antibody used in Immunohistochemistry (IHC). GTX27888

GTX27888 IHC Image

Immunohistochemistry of Bim in human skin cancer cells with Bim Antibody (Cat. No. GTX27888) at 20 μg/mL.

Anti-Bim antibody used in Western Blot (WB). GTX27888

GTX27888 WB Image

WB analysis of various sample lysates using GTX27888 Bim antibody.
Loading : 15μg of lysates per lane
Dilution : 5 μg/ml

Anti-Bim antibody used in Western Blot (WB). GTX27888

GTX27888 WB Image

Western blot analysis of Bim expression in human K562 (K) and A549 (A) cell lysates with Anti-Bim (Cat. No. GTX27888) at 2 μg/mL.

REFERENCE

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SDS
PBS.pdf
Package List Price ($)
$ 479