*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
No cross-reactivity with insulin. This antibody binds with equal efficiency to the human free C-peptide and C-peptide region in proinsulin molecules.
PBS pH 7.4, 0.09 % sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4º C.
Batch dependent (Please refer to the vial label for the specific concentration.)
Recombinant C-peptide construction.
Protein A purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
IDDM, IDDM1, IDDM2, ILPR, INS, IRDN, MODY10, insulin, Insulin
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]