GeneTex

  • Country / Location Selection

United States (US)

C1q antibody [JL-1] (FITC)

Cat. No. GTX54404-06

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 JL-1

Isotype

 IgG2b

Application

 WB, ICC/IF, IHC-Fr, Functional Assay, Depletion

Reactivity

 Human, Rat
Package
100 μg ($749)
See all C1q products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
Functional Assay Assay dependent
Depletion Assay dependent

Note :

Functional Assay
Antibody JL-1 was administered to mice resulting in depletion of circulating C1q, glomerular deposition of C1q and induction of anti-C1q autoantibodies in susceptible mice.
Not tested in other applications.

Product Note

The monoclonal antibody JL-1 is reactive with the collagen-like region (CLR) only, which is the same region to which autoantibodies in mice and humans are binding. Anti-C1q autoantibodies deposit in glomeruli together with C1q but induce overt renal disease only in the context of glomerular immune complex disease. This provides an explanation why anti-C1q antibodies are especially pathogenic in patients with SLE.

PROPERTIES

Form

Liquid

Buffer

0.2 μm filtered PBS, 1% BSA

Preservative

0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. Protect from light.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Purified mouse C1q

Purification

Protein G purified

Conjugation

Fluorescein isothiocyanate (FITC)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

complement C1q A chain , complement C1q B chain , complement C1q C chain , C1Q-C , C1QG

Cellular Localization

Secreted

Database

Research Area

REFERENCE

There are currently no references for C1q antibody [JL-1] (FITC) (GTX54404-06). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for C1q antibody [JL-1] (FITC) (GTX54404-06). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 749