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C3 antibody

Cat. No. GTX72994

Reference 3

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, FACS, Immunoelectrophoresis

Reactivity

 Human, Mouse, Rat, Rabbit, Hamster, Guinea pig, Pig, Baboon, Horse
Package
1 ml ($399)
See all C3 products

APPLICATION

Application Note

For FACS: 1/100. For ICC: 1/500 For Ie: Use at an assay dependent dilution. For WB: 1/1000. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

187 kDa. ( Note )

Positive Control

Purified C3 protein

Product Note

Monospecific to human C3 complement component. This antibody has also been reported to recognize the C3 fragments, C3a, C3b, and C3c.

PROPERTIES

Form

Liquid

Buffer

500mM NaCl, 50mM Tris-HCl pH7.5

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human complement C3

Conjugation

Unconjugated

RRID

AB_374787

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

complement C3 , AHUS5 , ARMD9 , ASP , C3a , C3b , CPAMD1 , HEL-S-62p

Cellular Localization

Secreted

Background

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]

Database

Research Area

REFERENCE

Application Reference

Kohn M et al. Front Immunol 2021; 12 : 626627 Complement and Chlamydia psittaci: Non-Myeloid-Derived C3 Predominantly Induces Protective Adaptive Immune Responses in Mouse Lung Infection.
Application : WB
Reactivity : Mouse
Lee HK et al. Theranostics 2020; 10 (22) : 10186-10199 Phorbol ester activates human mesenchymal stem cells to inhibit B cells and ameliorate lupus symptoms in MRL.Fas lpr mice.
Application : IHC-P
Reactivity : Mouse
Johswich KO et al. PLoS Pathog 2013; 9 (7) : e1003509 In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa.
Application : WB
Reactivity : Mouse
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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399