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C3 / C3c antibody (FITC)

Cat. No. GTX73472

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat, Goat, Sheep, Bovine, Cat, Dog, Guinea pig, Pig, Mink
Package
1 ml ($509)
See all C3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P 1:75-1:100

Note :

IHC-P
Antigen retrieval : Proteinase K 30 min at 37ºC
Not tested in other applications.

Calculated MW

187 kDa. ( Note )

Product Note

This antibody reacts with human C3c complement and with the C3c part of C3 and C3b.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

C3c Complement isolated from complement-activated human serum.

Purification

Purified IgG

Conjugation

Fluorescein isothiocyanate (FITC)

RRID

AB_374934

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

complement C3 , AHUS5 , ARMD9 , ASP , C3a , C3b , CPAMD1 , HEL-S-62p

Cellular Localization

Secreted

Background

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]

Database

Research Area

REFERENCE

Application Reference

Park SY et al. J Immunol 2008; 181 (9) : 6328-36 Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b.
Application : ICC/IF
Reactivity : Human
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 509