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C4d antibody [10-11]

Anti-C4d antibody [10-11] used in IHC (Paraffin sections) (IHC-P). GTX42598

Cat. No. GTX42598

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 10-11

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, IHC-Fr, ELISA

Reactivity

 Human
Package
100 μg ($979)
See all C4d products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF 1/250-1/600
IHC-P Assay dependent
IHC-Fr 1/100-1/750
ELISA 1/5000-1/20,000
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

Borate buffered saline

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Native C4d, from human plasma

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

C4B1 Antibody , CO4 Antibody , C4B2 Antibody , C4BD Antibody , C4B3 Antibody , C4B Antibody , complement component 4B (Chido blood group) Antibody , CPAMD3 Antibody , CH Antibody , C4B5 Antibody , C4F Antibody , C4B12 Antibody

Background

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008]

Research Area

DATA IMAGES

Anti-C4d antibody [10-11] used in IHC (Paraffin sections) (IHC-P). GTX42598

GTX42598 IHC-P Image

IHC-P analysis of human renal allograft tissue using GTX42598 C4d antibody [10-11].

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 979