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C5 antibody [046-10.2.2 (10-04)]

Cat. No. GTX42596

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 046-10.2.2 (10-04)

Isotype

 IgG1

Application

 WB, ELISA, Neutralizing/Inhibition

Reactivity

 Human
Package
100 μg ($579)
See all C5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ELISA Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

Neutralizing/Inhibition
In haemolysis inhibition studies it was found that Mouse anti Human C5 antibody, clone 046-10.2.2 will block C5 haemolytic activity (Harder et al. 2017).
Not tested in other applications.

Calculated MW

188 kDa. ( Note )

Product Note

This antibody recognizes secreted complement component 5 (C5).

PROPERTIES

Form

Liquid

Buffer

Borate buffered saline

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human C5

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

complement C5 , C5D , C5a , C5b , CPAMD4 , ECLZB

Cellular Localization

Secreted

Background

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Database

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 579