GeneTex
United States (US)

C5 antibody

Cat No. GTX28789

Host Sheep
Clonality Polyclonal
Isotype IgG
Application ID
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ID Assay dependent
Not tested in other applications.

Calculated MW

188 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Glycine buffered saline, 0.09% Sodium Azide, 0.1% E-amino-n-caproic acid (EACA), 0.01% Benzamidine, 1mM ethylenediaminetetraacetic acid (EDTA)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human C5, purified from plasma.

Purification

Purified by ion exchange chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

CPAMD4 Antibody , complement component 5 Antibody , C5b Antibody , C5a Antibody

Background

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Database

Package List Price ($)
$ 359