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C5 antibody

Anti-C5 antibody used in Western Blot (WB). GTX33052
Anti-C5 antibody used in IHC (Paraffin sections) (IHC-P). GTX33052

Cat No. GTX33052

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
Package
100 μl ($329)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

188 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1567-1676 of human C5 (NP_001726.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

complement C5 , C5D , C5a , C5b , CPAMD4 , ECLZB

Cellular Localization

Secreted

Background

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Database

Research Area

DATA IMAGES
Anti-C5 antibody used in Western Blot (WB). GTX33052

GTX33052 WB Image

WB analysis of various samples using GTX33052 C5 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-C5 antibody used in IHC (Paraffin sections) (IHC-P). GTX33052

GTX33052 IHC-P Image

IHC-P analysis of human stomach tissue using GTX33052 C5 antibody.
Dilution : 1:100

REFERENCE
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REVIEW
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Package List Price ($)
$ 329