C5L2 antibody [N3C1], Internal

Cat No. GTX100360

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	IHC-P, IHC-Fr, IHC
Reactivity	Human, Mouse
Package	100 μl ($329), 25 μl ($169)

See all C5L2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
IHC-P	Assay dependent
IHC-Fr	Assay dependent
IHC	Assay dependent

Not tested in other applications.

Calculated MW

36 kDa. ( Note )

Positive Control

Synthetic peptide: 1:8,000

PROPERTIES

Form

Liquid

Buffer

1XPBS, 50% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human C5L2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1240846

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

complement component 5a receptor 2 , C5L2 , GPF77 , GPR77

Cellular Localization

Cell membrane

Background

The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).[supplied by OMIM]