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C5L2 antibody [N3C1], Internal

Cat No. GTX100360

Reference 4

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P, IHC-Fr, IHC

Reactivity

 Human, Mouse
Package
100 μl ($329),
25 μl ($169)
See all C5L2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P Assay dependent
IHC-Fr Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

36 kDa. ( Note )

Positive Control

Synthetic peptide: 1:8,000

PROPERTIES

Form

Liquid

Buffer

1XPBS, 50% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human C5L2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

complement component 5a receptor 2 , C5L2 , GPF77 , GPR77

Cellular Localization

Cell membrane

Background

The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]).[supplied by OMIM]

Database

Research Area

REFERENCE

Application Reference

Medler TR et al. Cancer Cell 2018; 34 (4) : 561-578.e6 Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.
Application : IHC-P
Reactivity : Mouse
Martin IV et al. Am J Physiol Renal Physiol 2017; : ajprenal.00060.2017 Complement C5a receptors C5L2 and C5aR in renal fibrosis.
Application : IHC-P
Reactivity : Mouse
Zhang T et al. Hindawi 2017; (Epub) The controversial C5a receptor C5aR2 - its role in health and disease.
Application : IHC-P, IHC-Fr
Reactivity : Human
Vijayan S et al. Am J Pathol 2014; 184 (7) : 2123-33 High expression of C5L2 correlates with high proinflammatory cytokine expression in advanced human atherosclerotic plaques.
Application : IHC
Reactivity : Human
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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 329
$ 169