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CALHM1 antibody

Anti-CALHM1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85207
Anti-CALHM1 antibody used in Western Blot (WB). GTX85207
Anti-CALHM1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85207

Cat. No. GTX85207

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all CALHM1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

38 kDa. ( Note )

Positive Control

Rat Liver Tissue Lysate(GTX27943)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

CALHM1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1.The immunogen is located within amino acids 60 - 110 of CALHM1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

calcium homeostasis modulator 1 , FAM26C

Cellular Localization

Cell membrane; Multi-pass membrane protein,Endoplasmic reticulum membrane

Background

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-b (Ab) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Ab levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

Database

Research Area

DATA IMAGES

Anti-CALHM1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85207

GTX85207 IHC-P Image

IHC-P analysis of rat liver tissue using GTX85207 CALHM1 antibody.
Working concentration : 20 μg/ml

Anti-CALHM1 antibody used in Western Blot (WB). GTX85207

GTX85207 WB Image

WB analysis of rat liver tissue lysate using GTX85207 CALHM1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-CALHM1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85207

GTX85207 IHC-P Image

IHC-P analysis of rat liver tissue using GTX85207 CALHM1 antibody.
Working concentration : 5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399