0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Recombinant protein encompassing a sequence within the center region of human CARD8. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
CARDINAL antibody, DACAR antibody, DAKAR antibody, DKFZp779L0366 antibody, FLJ18119 antibody, FLJ18121 antibody, KIAA0955 antibody, MGC57162 antibody, NDPP antibody, NDPP1 antibody, TUCAN antibody, CARD8 antibody, apoptotic protein NDPP1 antibody, caspase recruitment domain-containing protein 8 antibody, CARD inhibitor of NF-kappaB-activating ligands antibody, tumor up-regulated CARD-containing antagonist of CASP9 antibody, tumor up-regulated CARD-containing antagonist of caspase nine antibody, "caspase recruitment domain family, member 8 antibody"
Cytoplasm , Nucleus
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. [provided by RefSeq]