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CBX1 / HP1 beta antibody

Anti-CBX1 / HP1 beta antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00736
Anti-CBX1 / HP1 beta antibody used in Western Blot (WB). GTX00736

Cat. No. GTX00736

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, ChIP assay

Reactivity

 Human, Hamster
Package
50 μg ($399)
See all CBX1 / HP1 beta products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:2000-1:10000
ICC/IF Assay dependent
ChIP assay Assay dependent
Not tested in other applications.

Calculated MW

21 kDa. ( Note )

Predict Reactivity

Mouse, Zebrafish, Drosophila, Chicken, Xenopus(>80% identity)

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized 0.12M Sodium Phosphate, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.44 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

synthetic peptide CNEDDDKKDDKN including the C-terminal sequence (176-185) of human HP1beta

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

chromobox 1 , CBX , HP1-BETA , HP1Hs-beta , HP1Hsbeta , M31 , MOD1 , p25beta

Cellular Localization

Nucleus

Background

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CBX1 / HP1 beta antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00736

GTX00736 ICC/IF Image

ICC/IF analysis of Baby Hamster Kidney cells using GTX00736 CBX1 / HP1 beta antibody.
Fixation : 4% PFA

Anti-CBX1 / HP1 beta antibody used in Western Blot (WB). GTX00736

GTX00736 WB Image

WB analysis of MCF-7 whole cell lysate using GTX00736 CBX1 / HP1 beta antibody.
Dilution : 1:1000

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Package List Price ($)
$ 399