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CCM2 antibody

Anti-CCM2 antibody used in IHC (Paraffin sections) (IHC-P). GTX33071
Anti-CCM2 antibody used in IHC (Paraffin sections) (IHC-P). GTX33071
Anti-CCM2 antibody used in Western Blot (WB). GTX33071
Anti-CCM2 antibody used in IHC (Paraffin sections) (IHC-P). GTX33071

Cat No. GTX33071

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
Package
100 μl ($329)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

49 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CCM2 (NP_113631.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

CCM2 scaffold protein , C7orf22 , OSM , PP10187

Cellular Localization

Cytoplasm

Background

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]

Database

Research Area

DATA IMAGES
Anti-CCM2 antibody used in IHC (Paraffin sections) (IHC-P). GTX33071

GTX33071 IHC-P Image

IHC-P analysis of mouse heart tissue using GTX33071 CCM2 antibody.
Dilution : 1:100

Anti-CCM2 antibody used in IHC (Paraffin sections) (IHC-P). GTX33071

GTX33071 IHC-P Image

IHC-P analysis of human liver tissue using GTX33071 CCM2 antibody.
Dilution : 1:100

Anti-CCM2 antibody used in Western Blot (WB). GTX33071

GTX33071 WB Image

WB analysis of MCF7 cell lysate using GTX33071 CCM2 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-CCM2 antibody used in IHC (Paraffin sections) (IHC-P). GTX33071

GTX33071 IHC-P Image

IHC-P analysis of rat heart tissue using GTX33071 CCM2 antibody.
Dilution : 1:100

REFERENCE
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REVIEW
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Package List Price ($)
$ 329