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United States (US)

CCR1 antibody

Cat No. GTX13240

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, ELISA
Reactivity Human
Package
50 μg ($319)
APPLICATION

Application Note

ELISA: Use at a dilution of 1/100000. ICC: Use at a dilution of 1/400. WB: Use at a dilution of 1/1000. Predicted molecular weight: 62.6 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

41 kDa. ( Note )

Positive Control

Immunocytochemistry on human peripheral blood leukocytes

Specificity/Sensitivity

Peptide sequence is < 50 % identical to other chemokine receptors in this region.
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.1% Sodium Azide; Constituents: PBS, 1mg/ml BSA. pH 7.2

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: TEDYDTTTEFDYGDATPC, corresponding to amino acids 7 - 24 of Human CCR1.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

C-C Motif Chemokine Receptor 1,Cd191,Ckr-1,Ckr1,Cmkbr1,Hm145,Mip1Ar,Scyar1,Ccr1

Cellular Localization

Cell Membrane

Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP3), and myeloid progenitor inhibitory factor 1 (MPIF1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Database

Research Area

REFERENCE
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Package List Price ($)
$ 319