ELISA: Use at a dilution of 1/100000. ICC: Use at a dilution of 1/400. WB: Use at a dilution of 1/1000. Predicted molecular weight: 62.6 kDa. Optimal dilutions/concentrations should be determined by the end user.
Immunocytochemistry on human peripheral blood leukocytes
Peptide sequence is < 50 % identical to other chemokine receptors in this region.
Preservative: 0.1% Sodium Azide; Constituents: PBS, 1mg/ml BSA. pH 7.2
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
1 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide: TEDYDTTTEFDYGDATPC, corresponding to amino acids 7 - 24 of Human CCR1.
Immunogen affinity purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
C-C Motif Chemokine Receptor 1,Cd191,Ckr-1,Ckr1,Cmkbr1,Hm145,Mip1Ar,Scyar1,Ccr1
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP3), and myeloid progenitor inhibitory factor 1 (MPIF1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.