GeneTex
United States (US)

CCR3 antibody [C2C3], C-term

GTX100342_39568_IHC_2_19011506_911.jpg
GTX100342_39568_IHC_19011506_284.jpg
GTX100342_39568_WB_19011506_759.jpg

Cat No. GTX100342

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

41 kDa. ( Note )

Positive Control

K562

Predict Reactivity

Rhesus Monkey(>80% identity)
PROPERTIES

Form

Liquid

Buffer

1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CCR3. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

CC-CKR-3 antibody, CD193 antibody, CKR3 antibody, CMKBR3 antibody, MGC102841 antibody, CCR3 antibody, C-C CKR-3 antibody, C-C chemokine receptor type 3 antibody, eosinophil eotaxin receptor antibody, CC chemokine receptor 3 antibody, CCR-3 antibody, eosinophil CC chemokine receptor 3 antibody, b-chemokine receptor antibody, chemokine (C-C motif) receptor 3 antibody

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]

Database

Research Area

DATA IMAGES
GTX100342_39568_IHC_2_19011506_911.jpg

GTX100342 IHC-P Image

CCR3 antibody [C2C3], C-term detects CCR3 protein at cytosol on human colon carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human colon carcinoma.
CCR3 antibody [C2C3], C-term (GTX100342) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

GTX100342_39568_IHC_19011506_284.jpg

GTX100342 IHC-P Image

CCR3 antibody [C2C3], C-term detects CCR3 protein at cytosol on human ovarian carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human ovarian carcinoma.
CCR3 antibody [C2C3], C-term (GTX100342) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

GTX100342_39568_WB_19011506_759.jpg

GTX100342 WB Image

Sample (30 ug of whole cell lysate)
A: K562
10% SDS PAGE
GTX100342 diluted at 1:1000

SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 319
$ 169