APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:1000 |
Not tested in other applications.
Calculated MW
Predict Reactivity
Chimpanzee, Rhesus Monkey(>80% identity)
PROPERTIES
Form
Liquid
Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol
Preservative
0.01% Thimerosal
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide encompassing a sequence within the Extracellular domain of human CCR5. The exact sequence is proprietary.
Purification
Purified by antigen-affinity chromatography.
Conjugation
Unconjugated
RRID
AB_2036494
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
C-C motif chemokine receptor 5 (gene/pseudogene) , CC-CKR-5 , CCCKR5 , CCR-5 , CD195 , CKR-5 , CKR5 , CMKBR5 , IDDM22
Cellular Localization
Cell membrane
Background
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Database
Research Area
DATA IMAGES
![Anti-CCR5 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX109635](/templates/default/js/lightbox/images/loading.gif "Anti-CCR5 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX109635")
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GTX109635 IHC-P Image
Immunohistochemical analysis of paraffin-embedded H1299 xenograft, using CCR5(GTX109635) antibody at 1:500 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min
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REFERENCE
There are currently no references for CCR5 antibody [N1N2], N-term (GTX109635). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CCR5 antibody [N1N2], N-term (GTX109635). Be the first to share your experience with this product.
![Anti-CCR5 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX109635](/upload/website/prouct_img/small/GTX109635/GTX109635_39967_IHC_w_23060500_183.webp "Anti-CCR5 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX109635")
![Anti-CCR5 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX109635](/upload/website/prouct_img/normal/GTX109635/GTX109635_39967_IHC_w_23060500_183.webp "Anti-CCR5 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX109635")