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CCR5 antibody

Anti-CCR5 antibody used in IHC (Paraffin sections) (IHC-P). GTX21673

Cat. No. GTX21673

Reference 3

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA, IHC

Reactivity

 Human, Macaque
Package
100 μg ($399)
See all CCR5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
IHC-P 1:300
ELISA 1:25,000
IHC Assay dependent
Not tested in other applications.

Calculated MW

41 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM KHPO₄, 140mM NaCl, 0.1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide 3YQVSSPIYDINYYTSEPCQKINVKQIAA30 corresponding to the N-terminal sequence of human CCR5

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_369019

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CC motif chemokine receptor 5 (gene/pseudogene),CCCKR5,CCR5,CD195,CKR5,CMKBR5,IDDM22,C-C motif chemokine receptor 5 (gene/pseudogene)

Cellular Localization

Cell membrane

Background

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

Database

Research Area

DATA IMAGES

Anti-CCR5 antibody used in IHC (Paraffin sections) (IHC-P). GTX21673

GTX21673 IHC-P Image

IHC-P analysis of human spleen tissue using GTX21673 CCR5 antibody.

REFERENCE

Application Reference

Ishida Y et al. Nat Commun 2020; 11 (1) : 5994 Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis.
Sugasawa H et al. Int J Cancer 2008; 122 (11) : 2535-41 Gastric cancer cells exploit CD4+ cell-derived CCL5 for their growth and prevention of CD8+ cell-involved tumor elimination.
Application : IHC
Reactivity : Human
Sugasawa H et al. J Surg Oncol 2008; 97 (5) : 445-50 Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer.
Application : IHC
Reactivity : Human
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Package List Price ($)
$ 399