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CD105 antibody [ENG/1327]

Anti-CD105 antibody [ENG/1327] used in Western Blot (WB). GTX34454

Cat No. GTX34454

Host Mouse
Clonality Monoclonal
Clone Name ENG/1327
Isotype IgG1
Application WB, ICC/IF
Reactivity Human
Package
100 μg ($429)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-2ug/ml for 60 minutes at RT
ICC/IF 1-2ug/ml
Not tested in other applications.

Calculated MW

71 kDa. ( Note )

Specificity/Sensitivity

CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Recombinant human Endoglin protein fragment (aa74-251) (exact sequence is proprietary)

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Endoglin , End , Hht1 , Orw1 , Eng

Background

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Database

Research Area

DATA IMAGES
Anti-CD105 antibody [ENG/1327] used in Western Blot (WB). GTX34454

GTX34454 WB Image

Western Blot of HeLa and A431 Cell Lysates with Endoglin / CD105 Monoclonal Antibody (ENG/1327).

REFERENCE
There are currently no references for CD105 antibody [ENG/1327] (GTX34454). Be the first to share your publications with this product.
REVIEW
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Package List Price ($)
$ 429