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CD11a antibody [WT.1] (Biotin)

Cat. No. GTX41339

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 WT.1

Isotype

 IgG2a

Application

 FACS, IP, IHC, Neutralizing/Inhibition

Reactivity

 Rat
Package
100 μg ($399)
See all CD11a products

APPLICATION

Application Note

BL: Use at an assay dependent dilution. Suitable for in vivo and in vitro systems. The Low Endotoxin Azide Free format is suggested for blocking studies. FACS: Use 0.5μg for 10^6 cells in 100μl volume. IHC: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

129 kDa. ( Note )

Product Note

Rat CD11a

PROPERTIES

Form

Liquid

Buffer

PBS, 0.5% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Rat Splenic PHA blasts

Purification

Purified Ig

Conjugation

Biotin

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin subunit alpha L , CD11A , LFA-1 , LFA1A

Cellular Localization

Cell membrane

Background

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399