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CD11b antibody [2LPM19c]

Anti-CD11b antibody [2LPM19c] used in Activation/Stimulation/Induction (Activation). GTX72023
Anti-CD11b antibody [2LPM19c] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX72023
Anti-CD11b antibody [2LPM19c] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX72023

Cat. No. GTX72023

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2LPM19c

Isotype

 IgG1

Application

 IHC-Fr, FACS, Activation, Neutralizing/Inhibition

Reactivity

 Human, Hamster
Package
500 μl ($399)
See all CD11b products

APPLICATION

Application Note

For a three-step avidin-biotin complex system, a dilution of 1:50 to 1:100 may be used as a guideline. Dilute according to the particular application being used. In general, the 0.05M Borate pH 8.0 containing 0.15M Sodium Chloride, 0.05% Sodium Azide, is a good diluent to use with most antibodies. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

127 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified C3bi Receptor

Purification

IgG fraction

Conjugation

Unconjugated

RRID

AB_383324

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin subunit alpha M , CD11B , CR3A , MAC-1 , MAC1A , MO1A , SLEB6

Cellular Localization

Cell membrane

Background

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Database

Research Area

DATA IMAGES

Anti-CD11b antibody [2LPM19c] used in Activation/Stimulation/Induction (Activation). GTX72023

GTX72023 Activation Image

The data was published in the journal Nat Commun in 2018. PMID: 29410422

Anti-CD11b antibody [2LPM19c] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX72023

GTX72023 Neutralizing/Inhibition Image

The data was published in the journal Nat Commun in 2018. PMID: 29410422

Anti-CD11b antibody [2LPM19c] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX72023

GTX72023 Neutralizing/Inhibition Image

The data was published in the journal Nat Commun in 2018. PMID: 29410422

REFERENCE

Application Reference

Wolf D et al. Nat Commun 2018; 9 (1) : 525 A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399