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CD11b antibody [OX-42] (PE)

Anti-CD11b antibody [OX-42] (PE) used in Flow cytometry (FACS). GTX76061
Anti-CD11b antibody [OX-42] (PE) used in Flow cytometry (FACS). GTX76061

Cat. No. GTX76061

Reference 11

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 OX-42

Isotype

 IgG2a

Application

 FACS

Reactivity

 Rat
Package
50 μg ($319)
See all CD11b products

APPLICATION

Application Note

Optimal dilutions/concentrations should be determined by the researcher.

PROPERTIES

Form

Liquid

Buffer

PBS, BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Protect from light.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Rat peritoneal macrophages

Purification

Protein G purified

Conjugation

Phycoerythrin (PE) Wavelength

RRID

AB_379190

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Integrin Subunit Alpha M , Cd11B , Itgam

Background

Recognises most macrophages (including resident peritoneal and activated macrophages), Kupffer cells, but only about 35% alveolar macrophages. The MRC OX-42 antibody also labels dendritic cells extensively, granulocytes and cells with the morphology of microglia in brain. MRC OX-42 precipitates three polypeptides of M.W 160,000, 103,000 and 95,000. The antibody inhibits complement mediated rosettes and is probably the rat equivalent of the human receptor for iC3b called CR3.

Research Area

DATA IMAGES

Anti-CD11b antibody [OX-42] (PE) used in Flow cytometry (FACS). GTX76061

GTX76061 FACS Image

Staining of rat peritoneal macrophages with Mouse anti Rat CD11b: Biotin (GTX53827)

Anti-CD11b antibody [OX-42] (PE) used in Flow cytometry (FACS). GTX76061

GTX76061 FACS Image

Staining of rat peritoneal macrophages with Mouse anti Rat CD11b (GTX76060)

REFERENCE

Clone Reference

Li S et al. Mol Med 2022; 28 (1):133 Bone marrow mesenchymal stem cell-derived exosomes shuttling miR-150-5p alleviates mechanical allodynia in rats by targeting NOTCH2 in microglia.
Lee H.P. et al. ournal of Functional Foods 2021; 86:104712 Cordycerebroside A suppresses VCAM-dependent monocyte adhesion in osteoarthritis synovial fibroblasts by inhibiting MEK/ERK/AP-1 signaling.
Aminzadeh A et al. Cell J 2020; 22 (Suppl 1):38-48 Investigating The Alterations of Oxidative Stress Status, Antioxidant Defense Mechanisms, MAP Kinase and Mitochondrial Apoptotic Pathway in Adipose-Derived Mesenchymal Stem Cells from STZ Diabetic Rats.
Truzzi F et al. Int J Mol Sci 2020; 22 (1) Pro-Inflammatory Effect of Gliadins and Glutenins Extracted from Different Wheat Cultivars on an In Vitro 3D Intestinal Epithelium Model.
Bai N et al. J Neuroinflammation 2020; 17 (1):45 G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense.
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REVIEW

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Application Reference
Nakajima H et al. J Neurotrauma 2012; 29 (8):1614-25 Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury.
Zhao Z et al. Glycoconj J 2009; 26 (2):173-88 Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes.
Application : FACS
Clone Reference
Li S et al. Mol Med 2022; 28 (1):133 Bone marrow mesenchymal stem cell-derived exosomes shuttling miR-150-5p alleviates mechanical allodynia in rats by targeting NOTCH2 in microglia.
Lee H.P. et al. ournal of Functional Foods 2021; 86:104712 Cordycerebroside A suppresses VCAM-dependent monocyte adhesion in osteoarthritis synovial fibroblasts by inhibiting MEK/ERK/AP-1 signaling.
Aminzadeh A et al. Cell J 2020; 22 (Suppl 1):38-48 Investigating The Alterations of Oxidative Stress Status, Antioxidant Defense Mechanisms, MAP Kinase and Mitochondrial Apoptotic Pathway in Adipose-Derived Mesenchymal Stem Cells from STZ Diabetic Rats.
Truzzi F et al. Int J Mol Sci 2020; 22 (1) Pro-Inflammatory Effect of Gliadins and Glutenins Extracted from Different Wheat Cultivars on an In Vitro 3D Intestinal Epithelium Model.
Bai N et al. J Neuroinflammation 2020; 17 (1):45 G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense.
Lin CH et al. Cell Mol Neurobiol 2019; 39 (5):591-604 Microglia-Derived Adiposomes are Potential Targets for the Treatment of Ischemic Stroke.
Bonfante R et al. Neuroscience 2018; 391:120-130 The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints.
Lin CH et al. PLoS One 2016; 11 (1):e0146692 Molecular Mechanisms Responsible for Neuron-Derived Conditioned Medium (NCM)-Mediated Protection of Ischemic Brain.
Takahashi K et al. Eur J Pain 2011; 15 (5):467.e1-14 IL-1beta in the trigeminal subnucleus caudalis contributes to extra-territorial allodynia/hyperalgesia following a trigeminal nerve injury.
SDS
Sodium Azide.pdf
Package List Price ($)
$ 319