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CD11c antibody [3.9]

Cat. No. GTX11029

Reference 8

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 3.9

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP, in vivo, Neutralizing/Inhibition

Reactivity

 Human, Mouse, Rat, Cynomolgus monkey, Rhesus Monkey
Package
500 μg ($399)
See all CD11c products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-10 μg/mL
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS ≤ 2 μg/10⁶ cells in a volume of 100 μL or 100μL of whole blood
IP Assay dependent
in vivo Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

128 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 150 mM NaCl

Preservative

No preservatives

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Rheumatoid synovial fluid cells and fibronectin purified human monocytes

Purification

Protein A/G purified

Purity

>95% by SDS-PAGE

Endotoxin

<0.5 EU/mg (determined by the LAL method)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD11C,ITGAX,SLEB6,integrin subunit alpha X,CD11c,Integrin alpha X

Cellular Localization

Membrane

Background

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Database

Research Area

REFERENCE

Clone Reference

2017; Effects of prenatal low protein and postnatal high fat diets on visceral adipose tissue macrophage phenotypes and IL-6 expression in Sprague Dawley rat offspring
Application : IHC-P
Reactivity : Rat
2014; Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer
Application : FACS
Reactivity : Cynomolgus monkey
2012; Viral Interferon Regulatory Factors Decrease the Induction of Type I and Type II Interferon during Rhesus Macaque Rhadinovirus Infection
Application : FACS
Reactivity : Rhesus Monkey
2009; Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions
Application : ICC/IF
Reactivity : Human
2008; Novel tools for functional analysis of CD11c: activation-specific, activation-independent, and activating antibodies
Application : Neutralizing/Inhibition
Reactivity : Human
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REVIEW

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Package List Price ($)
$ 399