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CD11c antibody [N418] (PE)

Anti-CD11c antibody [N418] (PE) used in Flow cytometry (FACS). GTX74941

Cat. No. GTX74941

Reference 11

Host

 Armenian Hamster

Clonality

 Monoclonal

Clone Name

 N418

Isotype

 IgG2

Application

 FACS

Reactivity

 Mouse
Package
100 μg ($419)
See all CD11c products
PRODUCT

Summary

The N418 antibody reacts with mouse CD11c, also known as integrin αalpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha X (CD11c) assembles with integrin αbeta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Not tested in other applications.

Calculated MW

129 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Mouse spleen dendritic cells.

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Phycoerythrin (PE)

RRID

AB_378303

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin alpha X , AI449405 , Cd11c , Cr4 , N418

Cellular Localization

Membrane

Database

Research Area

DATA IMAGES

Anti-CD11c antibody [N418] (PE) used in Flow cytometry (FACS). GTX74941

GTX74941 FACS Image

FACS analysis of C57Bl/6 splenocytes stained APC anti-mouse MHC Class II antibody, followed by staining with GTX74941 CD11c antibody [N418] (PE).
Right panel : Co-stained with APC anti-mouse MHC Class II antibody and GTX74941
Left panel : Co-stained with APC anti-mouse MHC Class II antibody and PE Armenian hamster IgG isotype control
Antibody amount : 0.25 μg

REFERENCE

Clone Reference

Matson KJE et al. Nat Commun 2022; 13 (1):5628 Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.
Ohno Y et al. Cancer Sci 2017; 108 (10):1959-1966 Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy.
Lin YL et al. Proc Natl Acad Sci U S A 2016; (Epub) in vivo amelioration of endogenous antitumor autoantibodies via low-dose p4n through the lta4h/* a/baff pathway.
2015; Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells
Ibrahim MK et al. Infect Immun 2014; Deficiency of lymph node resident dendritic cells and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.
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REVIEW

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Clone Reference
Matson KJE et al. Nat Commun 2022; 13 (1):5628 Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.
Ohno Y et al. Cancer Sci 2017; 108 (10):1959-1966 Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy.
Lin YL et al. Proc Natl Acad Sci U S A 2016; (Epub) in vivo amelioration of endogenous antitumor autoantibodies via low-dose p4n through the lta4h/* a/baff pathway.
2015; Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells
Ibrahim MK et al. Infect Immun 2014; Deficiency of lymph node resident dendritic cells and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.
Jackson NP et al. Eur J Immunol 2013; 43 (4):897-906 Salmonella polarises peptide-MHC-II presentation towards an unconventional Type B CD4+ T-cell response.
2011; DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity
2007; Corticosterone impairs dendritic cell maturation and function
2007; CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity
2006; Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration
1990; The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 419