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CD13 antibody [38C12]

Anti-CD13 antibody [38C12] used in IHC (Paraffin sections) (IHC-P). GTX01910

Cat. No. GTX01910

Host

Mouse

Clonality

Monoclonal

Clone Name

38C12

Isotype

IgG1

Application

IHC-P

Reactivity

Human
Package
500 μl ($679)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:80

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.

Not tested in other applications.

Calculated MW

110 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Recombinant prokaryotic fusion protein corresponding to the C-terminal region of the extracellular domain.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

alanyl aminopeptidase, membrane , APN , CD13 , GP150 , LAP1 , P150 , PEPN

Cellular Localization

Cell membrane

Background

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD13 antibody [38C12] used in IHC (Paraffin sections) (IHC-P). GTX01910

GTX01910 IHC-P Image

IHC-P analysis of human liver tissue using GTX01910 CD13 antibody [38C12]. Note staining of the bile canaliculi.

REFERENCE

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REVIEW

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Package List Price ($)
$ 679