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CD137 antibody [r4-1BB/4603]

Anti-CD137 antibody [r4-1BB/4603] used in IHC (Paraffin sections) (IHC-P). GTX02726

Cat. No. GTX02726

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 r4-1BB/4603

Isotype

 IgG2a

Application

 IHC-P

Reactivity

 Human
Package
100 μg ($529)
See all CD137 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 2-4 μg/ml

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA (pH 9.0) for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

28 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A recombinant fragment (around aa 19-188) of human CD137 protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TNF receptor superfamily member 9 , 4-1BB , CD137 , CDw137 , ILA

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD137 antibody [r4-1BB/4603] used in IHC (Paraffin sections) (IHC-P). GTX02726

GTX02726 IHC-P Image

IHC-P analysis of human kidney tissue section using GTX02726 CD137 antibody [r4-1BB/4603].

REFERENCE

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REVIEW

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Package List Price ($)
$ 529