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CD14 antibody [B365.1 (B-A8)]

Cat No. GTX72062

Host

Mouse

Clonality

Monoclonal

Clone Name

B365.1 (B-A8)

Isotype

IgG1

Application

ICC/IF

Reactivity

Human
Package
500 μl ($219)

APPLICATION

Application Note

Immunofluorescence 1:50-1:100 .

Calculated MW

40 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing 0.2% BSA and 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human Monocyte

Purification

Protein A affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cd14 Molecule , Cd14

Background

CD14 is a single copy gene encoding 2 protein forms: a 50 to 55 kDa glycosylphosphatidylinositol anchored membrane protein (mCD14) and a monocyte or liver derived soluble serum protein (sCD14) that lacks the anchor. Both molecules are critical for lipopolysaccharide (LPS) dependent signal transduction, and sCD14 confers LPS sensitivity to cells lacking mCD14. Increased sCD14 levels are associated with inflammatory infectious diseases and high mortality in gram negative shock. CD14 also appears to be involved in clearance of gram-negative bacteria via its high affinity binding to LPS-LPB complexes.

Database

Research Area

REFERENCE

REVIEW

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SDS
Sodium Azide.pdf