GeneTex
United States (US)

CD146 antibody [MUC18/1130]

GTX34461_20170712_IHC-P_18121410_276.jpg
GTX34461_20170712_IHC-P_2_18121410_396.jpg
GTX34461_20170712_IHC-P_1_18121410_501.jpg

Cat No. GTX34461

Host Mouse
Clonality Monoclonal
Clone Name MUC18/1130
Isotype IgG1
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:0.5-1.0ug/ml for 30 minutes at RT.

Calculated MW

72 kDa. ( Note )

Specificity/Sensitivity

The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human MUC18 protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
DATA IMAGES
GTX34461_20170712_IHC-P_18121410_276.jpg

GTX34461 IHC-P Image

Formalin-fixed, paraffin-embedded human Melanoma stained with MUC18 Monoclonal Antibody (MUC18/1130)

GTX34461_20170712_IHC-P_2_18121410_396.jpg

GTX34461 IHC-P Image

Formalin-fixed, paraffin-embedded human Tonsil stained with MUC18 Monoclonal Antibody (MUC18/1130)

GTX34461_20170712_IHC-P_1_18121410_501.jpg

GTX34461 IHC-P Image

Formalin-fixed, paraffin-embedded human Melanoma stained with MUC18 Monoclonal Antibody (MUC18/1130)

Package List Price ($)
$ 329