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CD146 antibody [N1238]

Anti-CD146 antibody [N1238] used in IHC (Paraffin sections) (IHC-P). GTX01919

Cat. No. GTX01919

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 N1238

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($589)
See all CD146 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:50

Note :

IHC-P
The recommended fixative is 10% neutral-buffered formalin for paraffin-embedded tissue sections. Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

72 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant fusion protein corresponding to a portion of the external domain of the human CD146 molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

melanoma cell adhesion molecule , CD146 , HEMCAM , METCAM , MUC18 , MelCAM

Cellular Localization

Membrane; Single-pass type I membrane protein

Database

Research Area

DATA IMAGES

Anti-CD146 antibody [N1238] used in IHC (Paraffin sections) (IHC-P). GTX01919

GTX01919 IHC-P Image

IHC-P analysis of human malignant melanoma using GTX01919 CD146 antibody [N1238]. Note membrane staining of metastatic melanocytes and endothelial cells.

REFERENCE

Application Reference

Shi J et al. Cancer Res 2023; 83 (22) : 3783-3795 A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody-Drug Conjugate for Targeting Melanoma.
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REVIEW

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Package List Price ($)
$ 589