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CD16 antibody [3G8]

Cat. No. GTX31047

Reference 4

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 3G8

Isotype

 IgG1

Application

 IHC-Fr, FACS, IP, ELISA, IHC, Neutralizing/Inhibition

Reactivity

 Human, Rhesus Monkey, Primate
Package
100 μg ($339)
See all CD16 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS 6 μg/ml
IP Assay dependent
ELISA Assay dependent
IHC Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

29 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human neutrophils

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Fc fragment of IgG receptor IIIa , CD16 , CD16A , FCG3 , FCGR3 , FCGRIII , FCR-10 , FCRIII , FCRIIIA , IGFR3 , IMD20

Cellular Localization

Cell membrane,Secreted

Background

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Clone Reference

A Smed-S?rensen et al. Blood 2008; 111 (10):5037 - 46 IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIa
Application : Neutralizing/Inhibition
Reactivity : Human
Holl V et al. J Immunol 2004; 173 (10):6274 - 83 Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophages
Application : Neutralizing/Inhibition
Reactivity : Human
D Hober et al. J Gen Virol 2002; 83 (Pt 9):2169 - 2176 Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-alpha by peripheral blood mononuclear cells from patients with type 1 diabetes
Application : Neutralizing/Inhibition
Reactivity : Human
O Mandelboim et al. Proc Natl Acad Sci U S A 1999; 96 (10):5640 - 4 Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity
Application : FACS, Neutralizing/Inhibition
Reactivity : Human
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339