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CD161 antibody [B199.2]

Cat. No. GTX42368

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 B199.2

Isotype

 IgG1

Application

 IHC-Fr, FACS, IP

Reactivity

 Human
Package
25 μg ($169)
See all CD161 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr Assay dependent
FACS 1/50-1/100
IP Assay dependent

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human NK cells cultured in IL-2 (Bennett et al. 1996)

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

killer cell lectin like receptor B1 , CD161 , CLEC5B , NKR , NKR-P1 , NKR-P1A , NKRP1A , hNKR-P1A

Cellular Localization

Membrane

Background

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Clone Reference

Williams KJ et al. Microbiol Immunol 2016; (Epub) Vaccinia Virus WR induces rapid surface expression of a host molecule detected by the antibody 4C7 that is distinct from CLEC2D.
Rosen DB et al. J Immunol 2008; 180 (10):6508-17 Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 169