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CD161 antibody [HP-3G10] (APC)

Anti-CD161 antibody [HP-3G10] (APC) used in Flow cytometry (FACS). GTX01454-07

Cat. No. GTX01454-07

Reference 174

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 HP-3G10

Isotype

 IgG1

Application

 FACS

Reactivity

 Human, Baboon, Chimpanzee, Rhesus Monkey
Package
100 test ($259)
See all CD161 products
PRODUCT

Summary

The HP-3G10 antibody is specific for human CD161, also known as NKR-P1A, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer which is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.The HP-3G10 antibody may be used for flow cytometric analysis of CD161 on NK and NKT cells, as well as on various T cell subsets. The antibody is also reported to be cross-reactive with Baboon, Chimpanzee and Rhesus CD161.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS 0.25 μg (5 μl) for 10⁵-10⁸ cells in 100 μl sample per test
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.05 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Allophycocyanin (APC)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

killer cell lectin like receptor B1 , CD161 , CLEC5B , KLRB1 , NKR , NKRP1 , NKRP1A , hNKRP1A

Cellular Localization

Membrane

Background

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD161 antibody [HP-3G10] (APC) used in Flow cytometry (FACS). GTX01454-07

GTX01454-07 FACS Image

FACS analysis of human peripheral blood lymphocytes using GTX01454-07 CD161 antibody [HP-3G10] (APC).
Solid lone : primary antibody
Dashed line : isotype control
antibody amount : 0.25 μg (5 μl)

REFERENCE

Clone Reference

Salio M et al. Proc Natl Acad Sci U S A 2020; 117 (19):10465-10475 Ligand-dependent downregulation of MR1 cell surface expression.
Sharma M et al. Front Immunol 2020; 11:1136 Mucosal-Associated Invariant T Cells Develop an Innate-Like Transcriptomic Program in Anti-mycobacterial Responses.
Schulte-Schrepping J et al. Cell 2020; Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Rodriguez L et al. Cell Rep Med 2020; 1 (5):100078 Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.
Sztein MB et al. Sci Rep 2020; 10 (1):13581 Salmonella enterica serovar Typhi exposure elicits ex vivo cell-type-specific epigenetic changes in human gut cells.
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Clone Reference
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Meermeier EW et al. Nat Commun 2016; 7:12506 Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.
Khaitan A et al. PLoS One 2016; 11 (8):e0161786 HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets.
Jiang J et al. Sci Rep 2016; 6:32320 Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling.
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Harms RZ et al. PLoS One 2015; 10 (1):e0117335 Altered CD161 bright CD8+ mucosal associated invariant T (MAIT)-like cell dynamics and increased differentiation states among juvenile type 1 diabetics.
Magalhaes I et al. J Clin Invest 2015; 125 (4):1752-62 Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients.
Nausch N et al. PLoS Negl Trop Dis 2015; 9 (3):e0003627 Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment.
Sharma PK et al. Immunology 2015; 145 (3):443-53 High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells.
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Leeansyah E et al. PLoS Pathog 2015; 11 (8):e1005072 Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.
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