The Binding of EDHu-1 occurs via the N-terminal region of CD163 containing the first three scavenger receptor, Cysteine-rich, SRCR
domains the third domain being critical as, cleavage of this domain at the major cleavage site
ASP-265 abrogates binding to the N-terminal fragment.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Leucocytes harvested from the pleural cavity of patients with idiopathic spontaneous pneumothorax
Purification
Protein A purified From tissue culture supernatant
Conjugation
Unconjugated
RRID
AB_11165403
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
CD163 molecule , M130 , MM130 , SCARI1
Background
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
IHC-Fr staining of a human tonsil with Mouse anti Human CD163 antibody, clone EDHu-1 (GTX42365), red in A and Mouse anti Human CD21 antibody, clone LB21 (GTX74728), green in B. C is the merged image with nuclei counterstained blue using DAPI. Low power
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GTX42365 IHC-Fr Image
IHC-Fr analysis of human tonsil tissue using GTX42365 CD163 antibody [EDHu-1].
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GTX42365 IHC-Fr Image
IHC-Fr staining of a human tonsil with Mouse anti Human CD163 antibody, clone EDHu-1 (GTX42365), red in A and Mouse anti Human CD21 antibody, clone LB21 (GTX74728), green in B. C is the merged image with nuclei counterstained blue using DAPI. Medium power
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GTX42365 IHC-Fr Image
IHC-Fr analysis of human tonsil tissue using GTX42365 CD163 antibody [EDHu-1].
Show More +
GTX42365 IHC-Fr Image
IHC-Fr analysis of human tonsil tissue using GTX42365 CD163 antibody [EDHu-1].
Show More +
GTX42365 IHC-Fr Image
IHC-Fr staining of a human tonsil with Mouse anti Human CD163 antibody, clone EDHu-1 (GTX42365), red in A and Mouse anti Human CD21 antibody, clone LB21 (GTX74728), green in B. C is the merged image with nuclei counterstained blue using DAPI. High power
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/small/GTX42365/GTX42365_822_IHC-Fr_18121410_987.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/small/GTX42365/GTX42365_826_IHC-Fr_18121410_282.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/small/GTX42365/GTX42365_823_IHC-Fr_18121410_589.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/small/GTX42365/GTX42365_824_IHC-Fr_18121410_986.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/small/GTX42365/GTX42365_825_IHC-Fr_18121410_749.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/small/GTX42365/GTX42365_821_IHC-Fr_18121410_924.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/normal/GTX42365/GTX42365_822_IHC-Fr_18121410_987.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/normal/GTX42365/GTX42365_826_IHC-Fr_18121410_282.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/normal/GTX42365/GTX42365_823_IHC-Fr_18121410_589.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/normal/GTX42365/GTX42365_824_IHC-Fr_18121410_986.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/normal/GTX42365/GTX42365_825_IHC-Fr_18121410_749.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")
![Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365](/upload/website/prouct_img/normal/GTX42365/GTX42365_821_IHC-Fr_18121410_924.jpg "Anti-CD163 antibody [EDHu-1] used in IHC (Frozen sections) (IHC-Fr). GTX42365")