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CD18 antibody [C71/16]

Cat No. GTX19580

Host Rat
Clonality Monoclonal
Clone Name C71/16
Isotype IgG2a
Application IHC-Fr, FACS, IP, IHC-F
Reactivity Mouse
Package
250 μg ($319)
APPLICATION

Application Note

FACS: Use 1μg for 10^6 cells. IHC-acetone fixed frozen tissue sections: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. The antibody precipitates a (Mr 150/90 kDa) heterodimer from mouse leukocytes. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

85 kDa. ( Note )

Positive Control

The mouse CD18 antigen is present on mouse T-cells, B-cells, NK cells, monocytes, macrophages and granulocytes.
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.09% Sodium Azide. Constituents: 1.0% BSA, 0.01M PBS. pH 7.2

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Cell membrane glycoproteins derived from BW5147 cells.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Integrin Subunit Beta 2,Cd18,Lad,Lcamb,Lfa-1,Mac-1,Mf17,Mfi7,Itgb2

Cellular Localization

Type I membrane protein.

Background

CD18 is an integrin: Integrin beta chain beta 2. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes.

Database

Research Area

REFERENCE
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REVIEW
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Package List Price ($)
$ 319