Immunohistochemistry: use at a dilution of 1 / 10 - 1 / 25 for 30 - 60 mins at RT (ABC method). Optimal dilutions / concentrations should be determined by the end user.
This antibody reacts with CD21 antigen of MW 145 kDa, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth promoting signals to the interior of the B cell.
This antibody contains sodium azide as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Batch dependent(Please refer to the vial label for the specific concentration.)
Purified receptor for the C3d fragment of the third complement component CR2.
Tissue culture supernatant
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
CD21, 120650, 1380, CR2, P20023, C3DR, SLEB9
CD21 also known as complement receptor 2 (CR2). C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23-signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.