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CD239 antibody [BRIC221]

Cat. No. GTX75681

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 BRIC221

Isotype

 IgG2b

Application

 WB, ICC/IF, IHC-Fr, FACS, ELISA

Reactivity

 Human, Pig
Package
200 μg ($459)
See all CD239 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

67 kDa. ( Note )

Product Note

This antibody recognizes an epitope in the fourth extracellular domain of CD239 (B-CAM).

PROPERTIES

Form

Liquid

Buffer

Tris-Glycine

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human erythrocytes.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_376961

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

basal cell adhesion molecule (Lutheran blood group) , AU , CD239 , LU , MSK19

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Database

Research Area

REFERENCE

Application Reference

Sakamoto TM et al. Microvasc Res 2013; 90 : 173-9 Increased adhesive and inflammatory properties in blood outgrowth endothelial cells from sickle cell anemia patients.
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 459