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CD3 antibody [SP7]

CD3-antibody-SP7_IHC (Formalin-fixed paraffin-embedded sections)_GTX16669-1_18121409_337.jpg
CD3-antibody-SP7_IHC_GTX16669-1_18121409_338.jpg
CD3-antibody-SP7_IHC_GTX16669-5_18121409_561.jpg
CD3-antibody-SP7_WB_GTX16669-1_18121409_687.jpg
CD3-antibody-SP7_IHC_GTX16669-6_18121409_855.jpg
CD3-antibody-SP7_IHC_GTX16669-2_18121409_937.jpg
CD3-antibody-SP7_IHC_GTX16669-7_18121409_814.jpg
CD3-antibody-SP7_IHC_GTX16669-9_18121409_536.jpg
CD3-antibody-SP7_IHC_GTX16669-4_18121409_639.jpg
CD3-antibody-SP7_IHC_GTX16669-3_18121409_604.jpg
CD3-antibody-SP7_IHC_GTX16669-10_18121409_176.jpg
CD3-antibody-SP7_FACS_GTX16669-1_18121409_604.jpg
CD3-antibody-SP7_IHC_GTX16669-8_18121409_455.jpg

Cat No. GTX16669

Host Rabbit
Clonality Monoclonal
Clone Name SP7
Isotype IgG
Application WB, IHC-P, IHC-Fr, FACS, IHC
Reactivity Human, Mouse, Rat, Rabbit, Sheep, Cat, Dog, Pig, Monkey, Baboon, Horse, Woodchuck
APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:100. Antigen retrieval is suggested by boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

Positive Control

Tonsil

Specificity/Sensitivity

This antibody is suitable for staining normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.
PROPERTIES

Form

Liquid

Buffer

TCS containing 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Tissue Culture Supernatant

Antigen Species

Human

Immunogen

Synthetic peptide: KAKAKPVTRGAGA, corresponding to amino acids 156-168 of Human CD3 epsilon chain.

Purification

Unpurified
From hybridoma culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

T3E, 186740, P09693, T3D, 916, CD3-GAMMA, 917, CD3GAMMA, TCRE, P20963, 186830, 186780, P04234, CD3ZETA, CD3H, CD3Q, CD3E, CD3, CD3-DELTA, TCRZ, 919, CD3Z, CD3G, 915, CD3-ZETA, 186790, T3G, CD3D, P07766, CD3DELTA, CD3 ZETA, CD3 GAMMA, CD3 DELTA

Cellular Localization

Type I membrane protein.

Background

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq]

Research Area

DATA IMAGES
CD3-antibody-SP7_IHC (Formalin-fixed paraffin-embedded sections)_GTX16669-1_18121409_337.jpg

GTX16669 IHC-P Image

Formalin fixed paraffin embedded human tonsil stained with CD3antibody (GTX16669)

CD3-antibody-SP7_IHC_GTX16669-1_18121409_338.jpg

GTX16669 IHC Image

Human Tonsil stained with anti-CD3 antibody

CD3-antibody-SP7_IHC_GTX16669-5_18121409_561.jpg

GTX16669 IHC Image

Human Reactive Lymph Node stained with anti-CD3 antibody

CD3-antibody-SP7_WB_GTX16669-1_18121409_687.jpg

GTX16669 WB Image

Western Blot analysis of Jurkat cell lysate with CD3 antibody

CD3-antibody-SP7_IHC_GTX16669-6_18121409_855.jpg

GTX16669 IHC Image

Human Cervix stained with anti-CD3 antibody

CD3-antibody-SP7_IHC_GTX16669-2_18121409_937.jpg

GTX16669 IHC Image

Human Thymus stained with anti-CD3 antibody

CD3-antibody-SP7_IHC_GTX16669-7_18121409_814.jpg

GTX16669 IHC Image

Human Breast Ductal Carcinoma stained with anti-CD3 antibody

CD3-antibody-SP7_IHC_GTX16669-9_18121409_536.jpg

GTX16669 IHC Image

Human Renal Cell Carcinoma stained with anti-CD3 antibody

CD3-antibody-SP7_IHC_GTX16669-4_18121409_639.jpg

GTX16669 IHC Image

Human Tonsil stained with anti-CD3 antibody

CD3-antibody-SP7_IHC_GTX16669-3_18121409_604.jpg

GTX16669 IHC Image

Human HK Lymphoma stained with anti-CD3 antibody

CD3-antibody-SP7_IHC_GTX16669-10_18121409_176.jpg

GTX16669 IHC Image

Human Uterus stained with anti-CD3 antibody

CD3-antibody-SP7_FACS_GTX16669-1_18121409_604.jpg

GTX16669 FACS Image

Flow cytometric analysis of rabbit anti-CD3 (SP7) antibody in Jurkat (green) compare to negative control of rabbit IgG (blue)

CD3-antibody-SP7_IHC_GTX16669-8_18121409_455.jpg

GTX16669 IHC Image

Human Lung Squamous Cell Carcinoma stained with anti-CD3 antibody

REFERENCE
Package List Price ($)
$ 339