GeneTex
United States (US)

CD3 antibody (ready-to-use)

GTX16930_IHC-P_18121410_768.jpg
CD3-antibody-ready-to-use_IHC (Formalin-fixed paraffin-embedded sections)_GTX16930-1_18121409_601.jpg

Cat No. GTX16930

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P: Ready to use, suggested incubation period of 30 minutes at room temperature. Optimal dilutions/concentrations should be determined by the end user.

Positive Control

Tonsil

Specificity/Sensitivity

Antibody reacts with intracytoplasmic portion of the CD3 antigen on the T cells. It stains T cells in cortex as well as medulla of the thymus and lymphoid tissues. This antibody also labels T cell neoplasm, malignant histiocytes and in Hodgkin's disease.
PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic peptide (Human) conjugated to BSA.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

T3E, 186740, P09693, T3D, 916, CD3-GAMMA, 917, CD3GAMMA, TCRE, P20963, 186830, 186780, P04234, CD3ZETA, CD3H, CD3Q, CD3E, CD3, CD3-DELTA, TCRZ, 919, CD3Z, CD3G, 915, CD3-ZETA, 186790, T3G, CD3D, P07766, CD3DELTA, CD3 ZETA, CD3 GAMMA, CD3 DELTA

Cellular Localization

Type I membrane protein.

Background

T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.

Research Area

DATA IMAGES
GTX16930_IHC-P_18121410_768.jpg

GTX16930 IHC-P Image

IHC-P analysis of human pituatory tissue using CD3 antibody.

CD3-antibody-ready-to-use_IHC (Formalin-fixed paraffin-embedded sections)_GTX16930-1_18121409_601.jpg

GTX16930 IHC-P Image

Formalin fixed paraffin embedded human tonsil stained with CD3 antibody (GTX16930)

Package List Price ($)
$ 329