GeneTex
United States (US)

CD3 epsilon antibody [145-2C11]

Cat No. GTX16181

Host Hamster
Clonality Monoclonal
Clone Name 145-2C11
Isotype IgG
Application FACS
Reactivity Mouse
APPLICATION

Application Note

FACS: Use 0.25μg for 10^6 cells. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

21 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Preservative: None Constituents: PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Tissue / cell preparation, H-2Kb-specific mouse cytotoxic T lymphocyte clone BM10-37.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd3 Antigen, Epsilon Polypeptide,Ai504783,Cd3,Cd3Epsilon,T3E,Cd3E

Cellular Localization

Cell Membrane

Background

T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.

Database

Research Area

Package List Price ($)
$ 319