GeneTex

  • Country / Location Selection

United States (US)

CD3 epsilon antibody

Cat. No. GTX20022

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-Fr, FACS, IP, IHC, RIA

Reactivity

 Human, Pig
Package
100 μg ($339)
See all CD3 epsilon products

APPLICATION

Application Note

This antibody is not suitable for use on paraffin sections.

Calculated MW

23 kDa. ( Note )

Product Note

Detects the non-glycosylated epsilon chain of CD3 (MW 20kD) which is closely associated on the lymphocyte cell surface with the T cell antigen receptor (TCR).The antibody reacts with T cells in the thymus, bone marrow, and peripheral blood and is able to induce proliferation of mature thymocytes and T cells with, and without the presence of IL-2.The majority of T cell neoplasms are positive with this antibody.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human infant thymocytes and Sezary cells

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_369096

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD3e molecule , IMD18 , T3E , TCRE

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Application Reference

Yarbrough WM et al. Circulation 2003; 108 (14) : 1753-9 Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling.
Application : IHC
Reactivity : Pig
Submit a Reference

REVIEW

There are currently no reviews for CD3 epsilon antibody (GTX20022). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 339
Custom Conjugations