GeneTex
United States (US)

CD35 antibody

GTX37450_20190129_IHC-P_2_19012901_579.jpg
GTX37450_20190129_WB_19012901_967.jpg
GTX37450_20190129_IHC-P_1_19012901_793.jpg
GTX37450_20190129_IHC-P_19012901_755.jpg

Cat No. GTX37450

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:100-2000
IHC-P 1:100-800 (based on 0.5 mg/ml)
Not tested in other applications.

Calculated MW

224 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

10 mM PBS, 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived from human CD35. Please contact us for the exact immunogen sequence.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Complement C3B/C4B Receptor 1 (Knops Blood Group),C3Br,C4Br,Cd35,Kn,Cr1

Cellular Localization

Membrane

Background

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX37450_20190129_IHC-P_2_19012901_579.jpg

GTX37450 IHC-P Image

IHC-P analysis of rat stomach tissue using GTX37450 CD35 antibody.
Dilution : 2.5μg/ml

GTX37450_20190129_WB_19012901_967.jpg

GTX37450 WB Image

WB analysis of rat pancreas (Lane 1), rat thymus (Lane 2), human breast cancer (Lane 3) tissue lysates using GTX37450 CD35 antibody.
Dilution : 1μg/ml

GTX37450_20190129_IHC-P_1_19012901_793.jpg

GTX37450 IHC-P Image

IHC-P analysis of human endometrial cancer tissue using GTX37450 CD35 antibody.
Dilution : 2.5μg/ml

GTX37450_20190129_IHC-P_19012901_755.jpg

GTX37450 IHC-P Image

IHC-P analysis of mouse lymph node tissue using GTX37450 CD35 antibody.
Dilution : 2.5μg/ml

Package List Price ($)
$ 339