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CD36 antibody [VM58]

Anti-CD36 antibody [VM58] used in Immunohistochemistry (IHC). GTX28140

Cat No. GTX28140

Host

Mouse

Clonality

Monoclonal

Clone Name

VM58

Isotype

IgG1

Application

ICC/IF, IHC-Fr, IHC

Reactivity

Human
Package
200 μl ($289)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF Assay dependent
IHC-Fr Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

53 kDa. ( Note )

Product Note

The monoclonal antibody VM58 is directed against the CD36 antigen, a 90kD glycoprotein, also called GP IIIb expressed on human platelets. The GP IV (GP IIIb) molecule has been shown to function as thrombospondin receptor on platelets and monocytes and as receptor for Plasmodium falciparum infected erythrocytes. The monoclonal antibody reacts with platelets, monocytes, macrophages, erythroblasts and (weakly) with B-cells. In immunohistology the monoclonal antibody reacts with some endothelial cells, adipocytes and the granular layer of the skin. The antibody VM58 induces Fc-receptor-dependent platelet aggregation after binding to platelet. The heterogeneity of the response found in healthy individuals is dependent on the polymorphism of the Fc RII on platelets.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

3mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human monocytes.

Purification

IgG fraction
Ammonium sulfate + DEAE-cellulose, gradient elution

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD36 molecule , BDPLT10 , CHDS7 , FAT , GP3B , GP4 , GPIV , PASIV , SCARB3

Cellular Localization

Cell membrane , Golgi apparatus , Apical cell membrane

Background

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

Database

Research Area

DATA IMAGES

Anti-CD36 antibody [VM58] used in Immunohistochemistry (IHC). GTX28140

GTX28140 IHC Image

REFERENCE

There are currently no references for CD36 antibody [VM58] (GTX28140). Be the first to share your publications with this product.

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 289