CD38 antibody [HB7] (PE)

Cat. No. GTX01499-08

Host	Mouse
Clonality	Monoclonal
Clone Name	HB7
Isotype	IgG1
Application	FACS
Reactivity	Human
Package	100 test ($329)

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View product citations for antibody GTX01499-08 on CiteAb

PRODUCT

Summary

The HB7 antibody is specific for human CD38, a 45 kDa type II transmembrane glycoprotein expressed on thymocytes, plasma cells, and monocytes as well as other non-hematopoietic cells. T and B lymphocyte expression is discontinuous and varies based on differentiation state – present on immature cells, low on intermediate stages, and high on activated mature cells. It is found on most CD34+ cells, but not on pluripotent stem cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
FACS	0.125 μg (5 μl) for 10⁵-10⁸ cells in 100 μl sample per test

Not tested in other applications.

Calculated MW

34 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.025 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Phycoerythrin (PE)

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD38 molecule , ADPRC 1 , ADPRC1 , CD38

Cellular Localization

Membrane

Background

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Database

Gene ID: 952 CD38
UniProt: P28907 CD38

Research Area

DATA IMAGES

GTX01499-08 FACS Image

FACS analysis of human peripheral blood monocytes using GTX01499-08 CD38 antibody [HB7] (PE).
Solid lone : primary antibody
Dashed line : isotype control
antibody amount : 0.125 μg (5 μl)