PRODUCT
Summary
The HIT2 antibody is specific for human CD38, a 45 kD type II transmembrane glycoprotein expressed on thymocytes, activated T and B cells, and monocytes as well as other non-hematopoietic cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 μg (5 μl) for 10⁵-10⁸ cells in 100 μl sample per test |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Human thymocytes in foetus
Purification
Purified by affinity chromatography
From tissue culture supernatant
Conjugation
Fluorescein isothiocyanate (FITC)
RRID
AB_625552
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CD38 molecule , ADPRC 1 , ADPRC1
Background
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Database
Research Area
DATA IMAGES
![Anti-CD38 antibody [HIT2] (FITC) used in Flow cytometry (FACS). GTX78364](/templates/default/js/lightbox/images/loading.gif "Anti-CD38 antibody [HIT2] (FITC) used in Flow cytometry (FACS). GTX78364")
|
GTX78364 FACS Image
FACS analysis of human peripheral blood lymphocytes using GTX78364 CD38 antibody [HIT2] (FITC).
Solid line : Primary antibody
Dashed line : FITC mouse IgG1 isotype control
Antibody amount : 0.5 μg
|
REFERENCE
There are currently no references for CD38 antibody [HIT2] (FITC) (GTX78364). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CD38 antibody [HIT2] (FITC) (GTX78364). Be the first to share your experience with this product.
![Anti-CD38 antibody [HIT2] (FITC) used in Flow cytometry (FACS). GTX78364](/upload/website/prouct_img/small/GTX78364/GTX78364_20201020_FACS_32_w_23061322_373.webp "Anti-CD38 antibody [HIT2] (FITC) used in Flow cytometry (FACS). GTX78364")
![Anti-CD38 antibody [HIT2] (FITC) used in Flow cytometry (FACS). GTX78364](/upload/website/prouct_img/normal/GTX78364/GTX78364_20201020_FACS_32_w_23061322_373.webp "Anti-CD38 antibody [HIT2] (FITC) used in Flow cytometry (FACS). GTX78364")