CD4 antibody [GK1.5] (APC)

Cat. No. GTX80146
Cat. No.  GTX80146
Anti-CD4 antibody [GK1.5] (APC) used in Flow cytometry (FCM). GTX80146
GTX80146 FCM Image

FACS analysis of C57Bl/6 splenocytes using GTX80146 CD4 antibody [GK1.5] (APC).
Solid line : Primary antibody
Dashed line : APC rat IgG2b isotype control
Antibody amount : 0.06 μg

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Anti-CD4 antibody [GK1.5] (APC) used in Flow cytometry (FCM). GTX80146
  • Host
    Rat
  • Clonality
    Monoclonal
  • Clone Name
    GK1.5
  • Isotype
    IgG2b
  • Applications
    FCM
  • Reactivity
    Mouse, Golden Syrian Hamster
Summary
The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
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