APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Neat |
|
Note :
FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
|
Not tested in other applications.
Calculated MW
Product Note
This antibody recognizes the human CD40.
PROPERTIES
Form
Liquid
Buffer
PBS, 1% BSA
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
CD40 Ig(Fc) fusion protein containing the EC region of human CD40 and Fc region of human IgG.
Purification
Purified IgG
Conjugation
Phycoerythrin (PE)
RRID
AB_376653
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CD40 molecule , Bp50 , CDW40 , TNFRSF5 , p50
Background
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
Database
Research Area
DATA IMAGES
![Anti-CD40 antibody [LOB7/6] (PE) used in Flow cytometry (FACS). GTX75205](/templates/default/js/lightbox/images/loading.gif "Anti-CD40 antibody [LOB7/6] (PE) used in Flow cytometry (FACS). GTX75205")
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GTX75205 FACS Image
Figure A. FITC conjugated mouse anti human CD19 and RPE conjugated Mouse IgG2a isotype control. Figure B. FITC conjugated mouse anti human CD19 and RPE conjugated mouse anti human CD40 (GTX75205). All experiments performed on red cell lysed Human peripheral blood gated on lymphocytes
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REFERENCE
There are currently no references for CD40 antibody [LOB7/6] (PE) (GTX75205). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CD40 antibody [LOB7/6] (PE) (GTX75205). Be the first to share your experience with this product.
![Anti-CD40 antibody [LOB7/6] (PE) used in Flow cytometry (FACS). GTX75205](/upload/website/prouct_img/small/GTX75205/GTX75205_2061_FACS_w_23061322_842.webp "Anti-CD40 antibody [LOB7/6] (PE) used in Flow cytometry (FACS). GTX75205")
![Anti-CD40 antibody [LOB7/6] (PE) used in Flow cytometry (FACS). GTX75205](/upload/website/prouct_img/normal/GTX75205/GTX75205_2061_FACS_w_23061322_842.webp "Anti-CD40 antibody [LOB7/6] (PE) used in Flow cytometry (FACS). GTX75205")