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CD40 antibody [LOB7/6] (PE)

Anti-CD40 antibody [LOB7/6] (PE) used in Flow cytometry (FACS). GTX75205

Cat No. GTX75205

Host

Mouse

Clonality

Monoclonal

Clone Name

LOB7/6

Isotype

IgG2a

Application

FACS

Reactivity

Human, Dog
Package
100 test ($409)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
FACS Neat

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.

Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Specificity/Sensitivity

This antibody recognizes the human CD40.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.09% Sodium Azide, 1% BSA

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

CD40 Ig(Fc) fusion protein containing the EC region of human CD40 and Fc region of human IgG.

Purification

Purified IgG

Conjugation

Phycoerythrin (PE)

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cd40 Molecule , Bp50 , Cdw40 , Tnfrsf5 , P50 , Cd40

Background

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

Database

Research Area

DATA IMAGES

Anti-CD40 antibody [LOB7/6] (PE) used in Flow cytometry (FACS). GTX75205

GTX75205 FACS Image

Figure A. FITC conjugated mouse anti human CD19 and RPE conjugated Mouse IgG2a isotype control. Figure B. FITC conjugated mouse anti human CD19 and RPE conjugated mouse anti human CD40 (GTX75205). All experiments performed on red cell lysed Human peripheral blood gated on lymphocytes

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409