GeneTex

  • Country / Location Selection

United States (US)

CD40 antibody [LOB7/6]

Cat. No. GTX75202

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 LOB7/6

Isotype

 IgG2a

Application

 FACS, IP, IHC

Reactivity

 Human
Package
200 μg ($399)
See all CD40 products

APPLICATION

Application Note

For flow cytometry: Use 10ul of the suggested working dilution (20μg/ml) to label 10^6 cells in 100ul. For immunohistochemistry: * This product requires protein digestion pre-treatment of paraffin-embedded sections prior to staining eg. pronase or trypsin. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

31 kDa. ( Note )

Positive Control

Tonsil

Product Note

Recognises the human CD40 cell surface antigen, a 48kD glycoprotein expressed by B lymphocytes and weakly by some monocytes.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Purified IgG

Conjugation

Unconjugated

RRID

AB_376650

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD40 molecule , Bp50 , CDW40 , TNFRSF5 , p50

Background

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

Database

Research Area

REFERENCE

There are currently no references for CD40 antibody [LOB7/6] (GTX75202). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for CD40 antibody [LOB7/6] (GTX75202). Be the first to share your experience with this product.
Submit a Review
SDS
Sodium Azide.pdf
Package List Price ($)
$ 399