GeneTex
CD40L / CD154 antibody [5C8] (APC)
Cat. No. GTX01484-07
Cat. No. GTX01484-07
![Anti-CD40L / CD154 antibody [5C8] (APC) used in Flow cytometry (FCM). GTX01484-07](/upload/website/prouct_img/normal/GTX01484-07/GTX01484-07_20200428_FACS24_w_23053121_895.webp)
GTX01484-07 FCM Image
FACS analysis of human PBMCs (with PMA and Ionomycin stimulation for 5 hrs) using GTX01484-07 CD40L / CD154 antibody [5C8] (APC).
Solid lone : primary antibody
Dashed line : isotype control
antibody amount : 0.25 μg (5 μl)
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![Anti-CD40L / CD154 antibody [5C8] (APC) used in Flow cytometry (FCM). GTX01484-07](/upload/website/prouct_img/middle/GTX01484-07/GTX01484-07_20200428_FACS24_w_23053121_895.webp){kind=small}
This CD40L / CD154 antibody [5C8] (APC) (GTX01484-07) is a mouse monoclonal antibody validated for detection of CD40L / CD154 by FCM. Reactivity has been shown in Human, Cynomolgus monkey, and Rhesus Monkey.
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HostMouse
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ClonalityMonoclonal
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Clone Name5C8
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IsotypeIgG2a
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ApplicationsFCM
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ReactivityHuman, Cynomolgus monkey, Rhesus Monkey
Summary
The 5C8 antibody reacts with human CD154 which is also known as CD40L (CD40 ligand). CD154 is a 39kDa member of the TNF-α superfamily and is predominantly expressed on activated T cells but is also expressed on NK cells, mast cells, basophils, and eosinophils. CD154 binds to CD40, a molecule that is expressed on antigen presenting cells including B cells, monocytes/macrophages, and dendritic cells. The interaction of CD154 and CD40 regulates the activation of antigen presenting cells and is critical for B cell costimulation.